Antivirals Will Play Key Role in COVID-19 Management

Rensselaer Polytechnic Institute experts are developing a decoy strategy that has shown promise as an antiviral for viruses including SARS-CoV-2, dengue, Zika, and influenza A.

Long-term management of the SARS-CoV-2 virus, which causes COVID-19, will be increasingly important. As with influenza, and mosquito-borne viruses, like Zika, developing better antivirals for such perennial threats will have to be a part of the plan.

Rensselaer Polytechnic Institute researchers Jonathan Dordick, a chemical engineer, and Robert Linhardt, a biochemist are developing one promising antiviral approach that uses a decoy to trap the virus before it can infect a cell.

This decoy strategy has shown promise in combating a number of viruses, including SARS-CoV-2, dengue, Zika, and influenza A.

Dordick and Linhardt, who is internationally recognized for his creation of synthetic heparin, focus on viruses that use glycoproteins to latch onto human cells, a trait common to many viruses, including coronaviruses. They study how viruses gain entry into human cells at the molecular level and identify safe, effective compounds to offer as a decoy.

In their most recent test of this viral decoy strategy on mammalian cells, Dordick and Linhardt demonstrated that a compound derived from edible seaweeds substantially outperforms remdesivir, the current standard antiviral used to combat COVID-19. Heparin, a common blood thinner, and a heparin variant stripped of its anticoagulant properties, performed on par with remdesivir in inhibiting SARS-CoV-2 infection in mammalian cells. Both compounds bind tightly to the spike protein on the surface of SARS-CoV-2, the same strategy the team employed in their previous viral work.

Source: Rensselaer Polytechnic Institute

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