This is a transmission electron microscopic (TEM) image of a cluster of smallpox viruses, which had been processed using a negative stain technique. Courtesy of CDC/Dr. Fred Murphy
HIV patients lose immunity to smallpox even though they were vaccinated against the disease as children and have had much of their immune system restored with antiretroviral therapy, according to a study published in the Journal of Infectious Diseases.
Called HIV-associated immune amnesia, the finding could explain why people living with HIV still tend to have shorter lives on average than their HIV-negative counterparts despite being on antiretroviral therapy. The study follows other research recently published in the journals Science and Science Immunology that found the immune systems of children who contracted measles similarly "forgot" their immunity against other illnesses such as influenza.
Mark K. Slifka, PhD, a professor of molecular microbiology and immunology at the Oregon Health & Science University School of Medicine and Oregon National Primate Research Center, led the study. Slifka and his colleagues compared the T-cell and antibody responses of a total of 100 HIV-positive and HIV-negative women who were vaccinated against smallpox in their youth.
The research team chose smallpox because its last known U.S. case was in 1949, meaning study subjects haven't recently been exposed to its virus, which would have triggered new T-cell and antibody responses.
They found the immune systems of HIV-positive women who were on antiretroviral therapy had a limited response when their blood was exposed to the vaccina virus, which is used in the smallpox vaccine. Normally, those vaccinated against smallpox have CD4 T cells that remember the virus and respond in large numbers when they're exposed again. Previous research has shown smallpox virus-specific CD4 T cells are maintained for up to 75 years after vaccination.
This finding happened despite the fact that antiretroviral therapy works by boosting CD4 T cell counts in HIV-positive patients. This indicates that while antiretroviral therapy may boost total T cell counts overall, it can't recover virus-specific T cells generated from prior childhood vaccinations.
Slifka and his colleagues plan to evaluate whether the same phenomenon occurs in HIV-infected men, and if people living with HIV also lose immune memory to other diseases.
Researchers who contributed to this study are affiliated with OHSU, SUNY Downstate, Georgetown University, Cornell University, University of Southern California and John Hopkins University.
This research was supported by the National Institutes of Health Public Health Service (grant U19 AI109948) and Oregon National Primate Research Center (grant 8P51 OD011092).
Reference: Archana Thomas, Ericka Hammarlund, Lina Gao, Susan Holman, Katherine G. Michel, Marshall Glesby, Maria C. Villacres, Elizabeth T. Golub, Nadia R. Roan, Audrey L. French, Michael H. Augenbraun, Mark K. Slifka, "Loss of Pre-Existing Immunological Memory among HIV Infected Women Despite Immune Reconstitution with Antiretroviral Therapy," Journal of Infectious Diseases, Dec. 23, 2019, DOI: 10.1093/infdis/jiz678, https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiz678/5684906?guestAccessKey=d83ee54b-1796-4cfc-a915-7e489b48351c
Source: Oregon Health & Science University School of Medicine