Lancet Opinion Piece Says COVID-19 Vaccination Potential Will Not Be Achieved Without Increased Production, Affordable Pricing, Global Availability, Successful Rollout

Having new COVID-19 vaccines will mean little if people around the world are unable to get vaccinated in a timely manner. Vaccines have to be affordable and available to all countries, and governments must have the administrative and political capacities to deliver them locally to ensure an effective global immunization strategy against COVID-19, say the authors of a health policy piece published in The Lancet.

Global distribution of safe vaccines is imperative for spurring economic recovery, protecting lives, achieving herd immunity, and minimizing the risk of new variants emerging against which existing vaccines are less effective.

The seven authors, who are leading experts in vaccines, health policy, and infectious disease, discuss potential challenges to production, affordability, allocation, and roll-out of an effective global vaccination strategy against COVID-19, and score the 26 leading vaccines using a traffic light system to indicate their potential contribution to achieving global vaccine immunity.

Dr. Olivier Wouters, lead author from the London School of Economics and Political Science, UK, says, "Several manufacturers have successfully developed COVID-19 vaccines in under 12 months, an extraordinary achievement. But the stark reality is that the world now needs more doses of COVID-19 vaccines than any other vaccine in history in order to immunize enough people to achieve global vaccine immunity. Unless vaccines are distributed more equitably, it could be years before the coronavirus is brought under control at a global level. The questions now are when these vaccines will become available, and at what price."

Scaling up vaccine production to meet global demand is a monumental challenge. Most countries still lack the domestic capacity to rapidly produce COVID-19 vaccines on their own, and the sheer number of vaccines that are needed places huge pressure on global supply chains for materials like glass vials and syringes.

With vaccine manufacturing capabilities limited to a handful of global regions and by the relationships agreed between specific vaccine developers and manufacturers, the authors say that developers should share knowledge, technology, and data with a wider group of manufacturers to produce more COVID-19 vaccines. They note that some vaccine developers are collaborating with manufacturers in other regions, but the terms of these agreements are not clear about who decides where the vaccine manufactured in that region will be supplied to (i.e., it may be shipped to another location, rather than being used in the country where it was manufactured).

The authors also point out that there have been several initiatives to facilitate the scale-up of global production. For instance, the WHO has called on member states and manufacturers to commit to sharing knowledge, intellectual property, and data on COVID-19 vaccines, but responses to this initiative have been limited.

With large amounts of public funding being invested into COVID-19 vaccines, the authors argue that funders should encourage vaccine developers to share their expertise to help expand global production. Governments and non-profit groups have committed unprecedented sums of money to the development of COVID-19 vaccines and the infrastructure to produce them at scale--with the top five vaccine manufacturers receiving between $957 million and $2.1 billion.

Scarce supply, coupled with advanced orders by the world's richest nations for billions of vaccine doses--enough to protect some populations several times over--creates challenges to achieving timely, universal access. COVAX (the global initiative to ensure access to COVID-19 vaccines for all countries) was set up to avoid this, but vaccine nationalism could leave COVAX with limited supplies.

"Securing large quantities of vaccines in this way amounts to countries placing widespread vaccination of their own populations ahead of the vaccination of health-care workers and high-risk populations in poorer countries", says co-author professor Mark Jit from the London School of Hygiene & Tropical Medicine, UK. "Based on known deals, governments in high-income countries representing 16% of the global population have secured at least 70% of doses available in 2021 from five leading vaccine candidates."

COVAX says it will need a further US$6.8 billion in funding to fulfil its aim to secure 2 billion doses by the end of 2021, including 1 billion vaccine doses for 92 LMICs. "With additional funding, COVAX could compete better in the global scramble for vaccines," explains Wouters. "Vaccines developed by Chinese, Indian, and Russian manufacturers may also offer a lifeline for the lowest-income nations if they show good results in phase 3 trials, allowing them to procure abundant doses of vaccines that have not yet been authorized in most high-income countries. Once authorized by WHO, these vaccines could also potentially contribute to the COVAX portfolio."

Affordability also remains a major concern, with some vaccine manufacturers setting prices for COVID-19 vaccines that are among the highest ever charged for a vaccine. Without price controls, low-income countries are unlikely to be able to afford or access enough vaccines to protect their populations--with the lowest prices developers have offered to any country or purchasing bloc ranging from US$5 to US$62 per course (see the table in the Article).

"The extensive involvement of public funders in COVID-19 vaccine development provides an opportunity to make these vaccines globally available and affordable. Governments can insist that, as a condition of getting public funding, companies engage in sufficient licensing to enable widespread global production, and they must set affordable prices," says co-author professor Kenneth Shadlen from the London School of Economics and Political Science, UK.

Many LMICs also face substantial logistical and administrative barriers to delivering vaccination programs, including infrastructure, vaccination registries, and cold storage. The review highlights important trade-offs between the leading 26 COVID-19 vaccines that can help governments decide which vaccines best suit their needs. For instance, while many multi-dose, ultra-cold storage vaccines are highly efficacious, resource-constrained countries might be better to use single-dose vaccines which only have to be kept refrigerated, and are in late stages of clinical development.

The distinct characteristics of leading COVID-19 vaccines generate trade-offs, which mean that a range of vaccines will be needed to bring the global pandemic under control.

Successful roll-out can also be hampered by vaccination hesitancy. New findings from a 32-country survey of potential acceptance of COVID-19 vaccines (involving almost 27,000 adults), conducted by the authors between October 2020 and December 2020, suggest that Vietnam (98%), India, China (both 91%), Denmark and South Korea (both 87%) had the highest proportion of respondents who said they would "definitely" or "probably" get vaccinated when a COVID-19 vaccine becomes available; while Serbia (38%), Croatia (41%), France, Lebanon (both 44%), and Paraguay (51%) reported the highest proportion of people saying they would "probably not" or "definitely not" be vaccinated.

"To overcome challenges in vaccine hesitancy and ensure that vaccines are administered to as many people as possible, governments need to do much better at building public trust in the safety of vaccines and to combat misinformation and rumors around COVID-19," says professor Heidi Larson, co-author from the London School of Hygiene & Tropical Medicine, UK. "This will require increasing vaccination knowledge and awareness, promoting community engagement, and making vaccines available in convenient and accessible locations. Vaccine manufacturers should aim for maximum transparency and scrutiny of their clinical trial data, and post-marketing safety surveillance with compensation schemes for severe adverse events in resource poor countries with poor consumer protection. These factors are vital to build confidence during vaccine roll-out."

 

10 Comments on "Lancet Opinion Piece Says COVID-19 Vaccination Potential Will Not Be Achieved Without Increased Production, Affordable Pricing, Global Availability, Successful Rollout"

  1. BEST FREE YouTube To MP3 Converter
    blog post

  2. This is a very interesting article. Please, share more like this!

    blog post

  3. CEO and Founder of Custom Software Development Company

    Mbunity Development is a custom software development company trusted since 2016.
    We provide custom software development and mobile application development for startups and enterprises across the globe.

    What’s on offer:

    – Custom Software Development
    – Mobile Application Development
    – Mobile Development
    – Cloud & DevOps
    – UI/UX Design

    Contact person
    Websites & Profiles: blog

  4. Практически каждый пользователь интернета сталкивается с вопросом, как скачать видео с сайта на компьютер.
    Ведь не всегда предоставляется возможность загрузить файлы с той или другой страницы.
    В таком случае используются:

    Ответ найдешь по ссылке: как скачать видео с любого сайта

    Собираясь скачать видео, обратите внимание, что
    оно может быть защищено авторскими правами, а значит его скачивание запрещено.

    Применение любого из способов не предусматривает наличия специальных навыков или знаний.
    Все они просты в реализации.
    Наша статья расскажет об основных методах
    загрузки роликов с просторов сети.
    Существует огромное количество плагинов, сервисов для сохранения файлов.
    Разобравшись, как скачать видео с сайта без программ, можно легко загружать любимые ролики.

  5. Youtube to MP3 Converter Online

    How to Convert YouTube to MP3?
    1. Open Youtube and copy the Youtube video URL you want to download in MP3.

    2. Paste the Youtube video URL in the Search box,
    Tool will fetch video info.
    3. Select the Audio format you need and click the “Convert” button.
    4. After the conversion is successfully completed, click the “Download” button.
    5. Once the Audio is downloaded, you can play it whenever and wherever you want.

    Why use YouTube to MP3 Converter?
    1. Unlimited MP3 Conversions, so you can convert all your
    videos.
    2. We use High-Speed encoders to convert YouTube to MP3 faster!

    3. We offer Unlimited Downloads, convert as much
    as you can!
    4. No Signup/Registration required, our service is totally free.

    5. We support multiple qualities, e.g., 64kbps, 128kbps,
    and 160kbps.

    Free Convert YouTube videos to mp3 in high quality on ytmp3 .
    Fast Convert and download youtube videos to music files for PC,
    Mobile, and tablets.

  6. Free Convert YouTube videos to mp3 in high quality on yt mp3 .
    Fast Convert and download youtube videos to music files for PC, Mobile, and
    tablets.

  7. This is a very interesting article. Please, share more like this!

    blog

  8. This is a very interesting article. Please, share more like this!

    web site

  9. Благодаря порно онлайн можно не только
    получить удовольствие и расслабиться,
    здесь много полезной информации.
    Кто-то может смотреть порно после работы, кто-то просто хочет подрочить в свободное время,
    а кому-то захочется узнать о фетишах
    и разнообразии сексуальных наслаждений.
    На нашем сайте porno-tv.org всех ждет классное
    порно онлайн, доступное совершенно бесплатно.

    И чтобы наслаждаться жарким сексом с потрясающими красотками,
    не нужно тратить много времени и сил.

  10. youtubedrive.com/how-to-download-videos-from-instagram
    offers the fastest habit of Youtube video download in mp3,
    mp4, SQ, HD, Full HD quality, plus a wide range of formats for free.
    Its the most convenient YouTube downloader youve ever tried!
    Download video and audio from Youtube to your pc or mobile and look it for yourself!

    1) Find and paste the URL of the video in the input field
    2) Click the green “Download” button to save it,
    or choose the format you like (MP3, MP4, WEBM, 3GP).

    3) Then click on the gray arrow on the right of the Download
    button in order to choose the preferred format.

    4) Now you can enjoy the videos and playlists offline!
    Works in Chrome, Firefox, or any other browser.

Leave a comment

Your email address will not be published.


*