Researchers Use Bacteriotherapy to Improve Symptoms of Atopic Dermatitis

In a new study out of University of California San Diego School of Medicine, researchers have identified a universal strain of bacteria derived from healthy human skin that can treat the most common type of eczema, also known as atopic dermatitis.

In the paper published Feb. 22, 2021, in Nature Medicine, the research team investigated the safety and mechanisms of this certain bacteria in a first-in-human, Phase I, double-blinded clinical trial looking to treat people living with eczema. Of the 54 participants, two-thirds reported improvements in their symptoms, including fewer complaints of itchiness and inflammation.

“The main question we wanted to answer was if this was safe. This was a safety study,” said Richard Gallo, MD, PhD, the Ima Gigli Distinguished Professor of Dermatology and chair of the Department of Dermatology at UC San Diego School of Medicine. “We found exactly what we hoped to find. The eczema of participants who received the bacterial treatment improved and there were no adverse events.”

Researchers screened more than 8,000 isolates of Staphylococcal bacteria derived from the skin of individuals without eczema, and identified a few strains that inhibited growth of Staphylococcal aureus, a pathogenic bacterium that aggravates skin conditions, such as eczema. These strains were evaluated for additional characteristics, such as decreased capacity to damage skin, and sensitivity to common antibiotics.

The screening resulted in the identification of a single strain of bacteria called Staphylococcus hominis A9 that could be used for the treatment of atopic dermatitis.

“That’s how we found the universal strain. This was one out of 8,000 strains that were tested in a dish for their ability to kill Staphylococcal aureus and treat atopic dermatitis,” said Gallo. “And it worked.”

The first tests were performed in animal models where mice were given an experimental version of eczema. Researchers then mixed Staphylococcus hominis with unscented lotion and applied the mixture to the mice twice daily for three days. After treatment, also known as bacteriotherapy, the mice were essentially cured of the eczema.

Success with these animal models led to the Phase I clinical trial using bacteriotherapy to treat 54 trial participants with eczema. Two-thirds of the participants showed a large reduction in S. aureus populations on their skin and improvement in their eczema.

“This research is a unique approach to targeting the harmful Staphylococcal aureus on atopic dermatitis skin with beneficial bacteria,” said study co-author Donald Leung, MD, allergist and immunologist at National Jewish Health and a co-author of the study. “It’s our hope this will help patients with eczema rid their skin of the harmful bacteria causing the inflammation. Future studies will determine if this new cream can be used for long periods’ of time to reduce the severity of eczema and improve the patient’s quality of life.”

Healthy human skin is alive with bacteria — there are more microorganisms living in and on the human body than there are human cells. Most microbes reside on human skin without causing harm, but in some people, bacterial pathogens can negatively alter a person’s health.

According to the National Eczema Association, nearly 18 million people in the United States have atopic dermatitis, the most common form of eczema, which is a chronic, itchy rash that commonly appears on the arms, legs and cheeks.

“From our research, we’ve determined this rational therapeutic approach for atopic dermatitis appears to be safe for people to use to treat their eczema,” said Gallo. “And it’s easy, too, because it’s just a cream and avoids the side effects of steroids and other drugs that target the immune system.”

Co-authors of the study include: Teruaki Nakatsuji, Tissa R. Hata, Yun Tong, Joyce Y. Cheng, Faiza Shafiq, Anna M. Butcher, Secilia S. Salem, Samantha L. Brinton, UC San Diego; Amanda K. Rudman Spergel, National Institutes of Health; Keli Johnson, Brett Jepson, Agustin Calatroni, Gloria David, Rho Federal Systems Division, Inc.; Marco Ramirez-Gama, and Patricia Taylor, National Jewish Health.

This research was funded, in part, by the Atopic Dermatitis Research Network (U19AI117673) and National Institute of Health (R01AR076082, R01AR064781 and R01AI116576).

Disclosure: Richard L. Gallo is a cofounder, consultant, member of the scientific advisory board and holds equity in MatriSys Bioscience, a company that is developing skin bacteriotherapy.

Source: University of California San Diego

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  126. In this great pattern of things you’ll secure an A just for hard work. Where you misplaced us ended up being in all the specifics. You know, they say, details make or break the argument.. And that couldn’t be much more correct right here. Having said that, allow me say to you just what did do the job. Your article (parts of it) is incredibly powerful and this is probably the reason why I am making an effort to comment. I do not make it a regular habit of doing that. Secondly, while I can certainly see a jumps in reason you come up with, I am definitely not certain of just how you appear to connect your points which in turn produce the conclusion. For now I will yield to your issue however hope in the near future you actually connect the facts much better.

  127. Thanks for the different tips contributed on this blog. I have observed that many insurance carriers offer consumers generous discounts if they opt to insure multiple cars together. A significant number of households currently have several motor vehicles these days, especially those with older teenage kids still living at home, and the savings upon policies could soon mount up. So it makes sense to look for a great deal.

  128. This is the proper weblog for anybody who wants to seek out out about this topic. You notice so much its almost exhausting to argue with you (not that I truly would need?HaHa). You undoubtedly put a brand new spin on a topic thats been written about for years. Great stuff, simply nice!

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  132. Terrific work! This is the type of information that should be shared around the net. Shame on Google for not positioning this post higher! Come on over and visit my website . Thanks =)

  133. You really make it seem so easy with your presentation but I find this matter to be actually something that I think I would never understand. It seems too complicated and very broad for me. I am looking forward for your next post, I?ll try to get the hang of it!

  134. I do love the way you have presented this difficulty plus it really does provide me personally a lot of fodder for thought. On the other hand, through what precisely I have personally seen, I really wish when the actual responses stack on that people keep on point and don’t embark on a tirade regarding the news of the day. Yet, thank you for this outstanding point and even though I can not necessarily concur with the idea in totality, I respect the perspective.

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  137. One thing I would like to say is that often car insurance cancellations is a dreaded experience and if you’re doing the appropriate things being a driver you simply will not get one. Many people do obtain the notice that they’ve been officially dumped by their own insurance company they then have to scramble to get added insurance following a cancellation. Affordable auto insurance rates are generally hard to get after the cancellation. Knowing the main reasons with regard to auto insurance canceling can help motorists prevent sacrificing one of the most vital privileges out there. Thanks for the ideas shared via your blog.

  138. Hello there, I found your site via Google while searching for a related topic, your website came up, it looks good. I’ve bookmarked it in my google bookmarks.

  139. magnificent points altogether, you simply gained a brand new reader. What would you suggest about your post that you made some days ago? Any positive?

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  141. Siemano noszę imię Witek. Kredyty- załatwię za Ciebie kwestie formalne. Aktualnie moim miejscem egzystencji jest estetyczne miasto Gostyń. Kredyty w Polsce- jak wiele długu będzie umorzone.

  142. Dzieńdoberek moje imię to Lucek. Kredyt sanok połączy Twoje chwilówki w jedno zobowiązanie. Na czas dzisiejszy moim miejscem bytowania jest przepiękne miasto Wejherowo. Kredyty w Polsce- doradztwo specjalisty dla mało zarabiających.

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  144. I mastered more a new challenge on this weight loss issue. Just one issue is that good nutrition is tremendously vital whenever dieting. A tremendous reduction in fast foods, sugary food, fried foods, sugary foods, red meat, and white flour products might be necessary. Keeping wastes organisms, and toxins may prevent objectives for fat-loss. While certain drugs temporarily solve the issue, the awful side effects are certainly not worth it, and so they never offer more than a temporary solution. This is a known undeniable fact that 95 of celebrity diets fail. Thank you for sharing your ideas on this blog site.

  145. Dżem dobry noszę imię Kajetan. Kredyty- powiem Ci jakie wytyczne musisz spełnić. Aktualnie moim miejscem egzystencji jest historyczne miasto Skarżysko Kamienna. Kredyty w Polsce to ratunek dla nadmiernie przekredytowanych.

  146. You could definitely see your expertise in the work you write. The sector hopes for more passionate writers like you who aren’t afraid to say how they believe. At all times go after your heart.

  147. One thing I’d really like to comment on is that weightloss routine fast may be accomplished by the suitable diet and exercise. A person’s size not just affects the look, but also the actual quality of life. Self-esteem, depressive disorder, health risks, as well as physical abilities are damaged in extra weight. It is possible to just make everything right and at the same time having a gain. In such a circumstance, a condition may be the offender. While a lot food but not enough physical exercise are usually guilty, common health concerns and widespread prescriptions might greatly enhance size. Thanks for your post here.

  148. Nice post. I learn something totally new and challenging on blogs I stumbleupon everyday. It will always be helpful to read content from other writers and practice a little something from other web sites.

  149. Nice post. I learn something totally new and challenging on blogs I stumbleupon on a daily basis. It will always be helpful to read through articles from other authors and practice something from their sites.

  150. I like it whenever people come together and share ideas. Great blog, keep it up!

  151. Dzień dobry moje imię to Ryszard. Kredyty to rzecz nad którą pracuje aktualnie. W tej chwili moim miejscem przebywania jest artystyczne miasto Radomsko. Kredyty w Polsce- doradztwo specjalisty dla niewiele zarabiających.

  152. It’s hard to find well-informed people about this topic, but you sound like you know what you’re talking about! Thanks

  153. Everyone loves it whenever people come together and share thoughts. Great blog, stick with it.

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  155. I am now not certain the place you are getting your info, however good topic. I must spend a while studying more or working out more. Thanks for wonderful info I used to be in search of this information for my mission.

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  157. Hello, i believe that i saw you visited my site thus i got here to ?return the prefer?.I am trying to find things to enhance my website!I suppose its adequate to make use of some of your concepts!!

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  159. You can definitely see your expertise within the work you write. The world hopes for more passionate writers such as you who are not afraid to mention how they believe. All the time go after your heart.

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  165. Great blog post. What I would like to add is that computer memory ought to be purchased in case your computer can’t cope with everything you do by using it. One can deploy two RAM boards containing 1GB each, as an illustration, but not certainly one of 1GB and one with 2GB. One should check the maker’s documentation for the PC to make certain what type of ram is necessary.

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  167. I do agree with all of the ideas you’ve presented in your post. They’re very convincing and will definitely work. Still, the posts are too short for novices. Could you please extend them a bit from next time? Thanks for the post.

  168. I know of the fact that currently, more and more people will be attracted to digital cameras and the field of digital photography. However, like a photographer, you should first invest so much time period deciding the model of digital camera to buy along with moving from store to store just so you could possibly buy the most inexpensive camera of the brand you have decided to settle on. But it doesn’t end now there. You also have take into consideration whether you should obtain a digital photographic camera extended warranty. Many thanks for the good ideas I accumulated from your website.

  169. Good article. I definitely appreciate this website. Keep writing!

  170. Right here is the perfect website for everyone who would like to understand this topic. You realize so much its almost tough to argue with you (not that I actually will need to…HaHa). You definitely put a brand new spin on a topic which has been discussed for many years. Great stuff, just wonderful.

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  172. certainly like your web-site but you need to check the spelling on quite a few of your posts. Several of them are rife with spelling problems and I find it very troublesome to tell the truth nevertheless I will definitely come back again.

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  174. Another thing I’ve noticed is always that for many people, less-than-perfect credit is the results of circumstances above their control. For example they may have already been saddled through an illness and because of this they have higher bills going to collections. Maybe it’s due to a job loss or inability to work. Sometimes divorce proceedings can really send the finances in the undesired direction. Thanks for sharing your notions on this blog.

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