Role of Hospital Environment in Transmission of Multidrug-resistant Gram-negative Organisms

Infections by multidrug-resistant (MDR) Gram-negative organisms (GN) are associated with a high mortality rate and present an increasing challenge to the healthcare system worldwide. In recent years, increasing evidence supports the association between the healthcare environment and transmission of MDRGN to patients and healthcare workers. To better understand the role of the environment in transmission and acquisition of MDRGN, Chia, et al. (2020) conducted a utilitarian review based on literature published from 2014 until 2019.

Multidrug-resistant (MDR) Gram-negative (GN) organisms (MDRGN), specifically carbapenem-resistant (CR) organisms, are a recognized healthcare problem worldwide. Various mechanisms are involved in the development of carbapenem resistance depending on the bacterial species. However, since their discovery, carbapenemases (e.g., NDM, KPC, and OXA) have emerged as key drivers of carbapenem resistance across various Gram-negative bacterial species. Lack of effective treatment and the consequent high mortality has increased emphasis on the prevention of MDRGN transmission. Prevention toolkits and guidelines have been drawn up by various organizations to harness the principles of infection control and prevention to break the chain of transmission and control the spread of MDRGN.

Reference: Chia PY, et al. The role of hospital environment in transmissions of multidrug-resistant gram-negative organisms
Antimicrobial Resistance & Infection Control. Vol. 9, No. 29. 2020.

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