Study Proposes a Resilience Approach for Accurate Diagnosis of HBV-Related Diseases Through Blood Tests

(a) Phase transition diagrams between CHB, LC, and HCC due to chronic HBV infection, including the situation of acute-on-chronic liver failure (ACLF) and death from HCC. Each blue ball represents a patient with the corresponding liver disease. When the ball crosses the peak, the patient undergoes a phase transition to the next state. (b–d) Networks of the clinical test items of CHB, LC, and HCC are constructed. Different colors of the nodes represent their degrees, and the link thickness indicates the strength of the correlations between items. Red lines indicate a negative correlation between items. (e–g) Three radar charts illustrating the topology structure of the corresponding networks. Courtesy of Gege Hou et al.

Chronic hepatitis B virus (HBV) infection poses a significant threat to global public health, contributing to liver-related morbidity and mortality. The current diagnostic methods for HBV-related diseases, such as laboratory tests, ultrasounds, computed tomography (CT), and liver biopsies, often overlap and consume valuable medical resources. In response to this challenge, a team of researchers have developed an innovative and cost-effective method to diagnose and predict HBV-related diseases based on blood tests.

In an innovative research article published in the journal Engineering, titled “A Resilience Approach for Diagnosing and Predicting HBV-Related Diseases Based on Blood Tests,” scientists introduce a novel measure called functional resilience. By constructing complex network models using clinical blood tests, the researchers have successfully assessed the liver conditions of patients with chronic HBV infection. Their approach combines network models and dynamics to identify pivotal indicators and corresponding thresholds, enabling early detection and prevention of disease deterioration.

The research team achieved an impressive macro-averaged precision of 84.74% using their method, functional resilience. In comparison, physicians relying solely on their experience, without assistance from imaging or biopsy, achieved a macro-averaged precision of 55.64%. From an economic standpoint, this approach has the potential to save at least 30 USD per visit for most Chinese patients and 400 USD for most US patients, compared to traditional diagnostic methods. Globally, the estimated annual savings could surpass 10.5 billion USD.

By comprehensively evaluating the condition of patients’ livers, this innovative diagnostic method reduces the need for excessive imaging exams, thus optimizing the use of medical resources during the diagnosis of liver diseases. The research findings provide a significant contribution to the field of HBV-related disease prevention and management.

The study’s conclusions shed light on the liver function status of patients with chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC) from a network perspective. By constructing networks based on 25 blood test items, the researchers analyzed the evolution dynamics of liver function and identified pivotal indications and related thresholds for critical states between CHB, LC, and HCC. This breakthrough discovery has profound implications for future HBV-related disease-prevention research, offering insights into the early warning signs of liver function deterioration.

The research team’s simulation of the progressive liver dysfunction caused by chronic HBV infection through the deletion or alteration of network links provides valuable insights into the transition between states. While the morphology of the liver in a critical state remains unknown, these findings inspire future research and pave the way for improved diagnosis, prevention, and treatment strategies.

The impact of this research extends beyond scientific and medical communities, as it addresses a pressing global health issue. By streamlining the diagnosis process and reducing medical costs, this novel approach has the potential to transform the lives of millions of patients affected by HBV-related diseases worldwide.

The paper “A Resilience Approach for Diagnosing and Predicting HBV-Related Diseases Based on Blood Tests,” authored by Gege Hou, Yunru Chen, Xiaojing Liu, Dong Zhang, Zhimin Geng, Shubin Si. Full text of the open access paper: