University’s Trial Indicates Hydroxychloroquine Does Not Prevent COVID-19 in Healthcare Workers

University of Minnesota Medical School physician researchers studied hydroxychloroquine as a treatment to prevent COVID-19 for those with high-risk for exposure to the virus -- healthcare workers.

The pre-exposure prophylaxis trial results, which were published in Clinical Infectious Diseases, determined that taking 400mg of hydroxychloroquine once or twice weekly did not prevent the development of COVID-19 in healthcare workers better than the placebo.

"This randomized placebo-controlled trial launched on April 6, with the objective of evaluating whether or not hydroxychloroquine taken once or twice weekly in healthcare workers at high risk for COVID-19 exposure could prevent COVID-19 infection," said principal investigator Radha Rajasingham, MD, an infectious diseases physician and researcher at the U of M Medical School.

The double-blind trial enrolled 1,483 healthcare workers and first responders from across the U.S. and Canada. Participants were randomly assigned to receive once-weekly hydroxychloroquine, twice-weekly hydroxychloroquine or placebo. Participants were followed for a minimum of four weeks and up to 12 weeks to evaluate who developed COVID-19.

Overall, 7.9% assigned the placebo developed COVID-19, while 5.9% assigned hydroxychloroquine developed COVID-19. Those results were not statistically significant, meaning there was not a meaningful difference between hydroxychloroquine and the placebo. Side effects were reported in 21% of participants assigned the placebo; 31% in the once-weekly hydroxychloroquine group and 36% in the twice-weekly hydroxychloroquine group. The most common side effects were nausea, upset stomach and diarrhea. There was no increased risk of serious side effects or cardiac complications from taking hydroxychloroquine compared to the placebo.

The research team from the University of Minnesota included David Boulware, MD, MPH; Sarah Lofgren, MD; Caleb Skipper, MD; and Matthew Pullen, MD, from the U of M Medical School; statisticians Ananta Bangdiwala, Nicole Engen and Kathy Hullsiek, PhD, from the U of M School of Public Health, Melanie Nicol, PharmD, PhD, from the U of M College of Pharmacy, among many students and trainees. The study was in collaboration with colleagues at Vanderbilt University and Oregon Health & Science University.

Source: University of Minnesota Medical School


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