Simplified Diagram: A new process to evaluate multiple disease outbreak models will help inform public health policy decisions for managing the outbreak. The process is currently being applied to the current COVID-19 outbreak. Courtesy of Will Probert, University of Oxford
An International group of researchers, including the University of Warwick, have developed a new process to harness multiple disease models for outbreak management, meaning public health agency can understand the merits of different management options in testing times such as these currently experienced with COVID-19.
During a disease outbreak, many research groups independently generate models, for example projecting how the disease will spread, which groups will be impacted most severely, or how implementing a particular management action might affect these dynamics. These models help inform public health policy for managing the outbreak.
“While most models have strong scientific underpinnings, they often differ greatly in their projections and policy recommendation,” said lead author Katriona Shea, professor of biology and Alumni Professor in the Biological Sciences, Penn State. “This means that policymakers are forced to rely on consensus when it appears, or on a single trusted source of advice, without confidence that their decisions will be the best possible.”
At the onset of an outbreak, a large amount of information is often unavailable or unknown, and researchers must make decisions about how to incorporate this uncertainty into their models, leading to differing projections.
In the paper, ‘Harnessing multiple models for outbreak management’ publishing 8th May in the journal Science, researchers propose a three-part process as follows:
- Multiple research groups first create models for specified management scenarios independently, to encourage a wide range of ideas without prematurely conforming to a certain way of thinking.
- The modeling groups formally discuss their models with each other—an important addition to previous multiple model methods—which allows them to examine why their models might disagree.
- Finally, the groups work independently again to refine their models, based on the insights from the discussion and comparison stage.
After group discussion and individual model refinement, the models are combined into an overall projection for each management strategy, which can be used to help guide risk analysis and policy deliberation. At this stage, methods from the field of decision analysis can allow the decision maker, for example a public health agency, to understand the merits of different management options in the face of the existing uncertainty.
The combined results can also help identify which uncertainty - what pieces of missing information - are most critical to learn about in order to improve models and thus improve decision making, providing a way to prioritize research directions.
Researchers plan to implement this process immediately for COVID-19, by taking advantage of the many research groups already producing models for the current outbreak, the strategy should be easy to implement while producing more robust results from the existing process.
Dr. Mike Tildesley, from the School of Life Sciences at the University of Warwick comments, “Even after initial decisions are made, the process can continue as new information about the outbreak and management becomes available. This ‘adaptive management’ strategy can allow researchers to refine their models and make new predictions as the outbreak progresses.
“For COVID-19, this process might inform how and when isolation and travel bans are lifted, and if these or other measures might be necessary again in the future.”
Shea adds, “This method can provide a framework for future outbreak settings, including emerging diseases and agricultural pest species, and management of endemic infectious diseases, including vaccination strategies and disease surveillance.”
In addition to Shea and Tildesley, the research team includes Michael Runge a research ecologist at the U.S. Geological Survey’s Patuxent Wildlife Research Center, David Pannell at the University of Western Australia, William Probert at the University of Oxford in the United Kingdom, Shou-Li Li at Lanzhou University in China and Matthew Ferrari at Penn State.
This work was supported by the National Science Foundation and the Penn State Huck Institutes of the Life Sciences though the Coronavirus Research Seed Fund.
Source: University of Warwick